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3282-30-2
bosschemical
3282-30-2
Pivaloyl chloride
CAS No. 3282-30-2
Alias: 2,2-dimethyl-propanoylchlorid;Acetyl chloride, trimethyl-;Neopantanoyl chloride;Pivalolyl chloride;pivaloyl;PIVALOYL CHLORIDE(PVCL);Pivaloyl chloride(Trimethylacetyl chloride);
Molecular formula：C5H9ClO
Molecular weight：120.58
Structural formula：
1.Performance and use:
It is colourless liquid, m.p.-56℃, b.p.105～106℃, n20D1.4120, relative density 0.9790, decompose in water, soluble in ether, benzene, toluene and other solvents.
Uses Trimethylacetyl chloride, also known as pivaloyl chloride, is the intermediate for the production of carbamate insecticide azoxystrobin, and also the intermediate for the herbicide isoemazolone, can be used as a raw material for the synthesis of amide and phenolic ester drugs, used in the production of (hydroxy)benzylpenicillin, cephalosporin (hydroxy)benzyl, ceftolozolin, bis(pivaloyl) adrenaline, etc, and is also used in the synthesis of tert-butyl tert-butyl peroxovaleric acid and other drugs.
Pivaloyl chloride can be used as the intermediate of semi-synthetic penicillin and cephalosporin, as well as the intermediate of pesticide, the intermediate of organic yellow agent of photographic material. In addition, it can be used as an acylating agent for ammonia, Schiff base, pyrrolidone and alcohols.
It is an important acylation reagent. The main role is as a pharmaceutical intermediate, such as for the production of hydroxybenzylpenicillin cefadroxil, cefazolin and bis-pivaloyl adrenaline and other drugs. UsesWidely used as an N-acylating agent for amines, Schiff bases and pyrrolidones, and as an O-acylating agent for alcohols, lactones and sugars.
2.Technical indicators:
ITEM | STANDARD SPEC. | TEST RESULT |
Appearance |
Colorless transparent liquid |
Colorless transparent liquid |
Pivaloyl Chloride | ≥99% | 99.13% |
Pivalic acid | ≤0.25% | 0.20% |
Pivalic anhydride | ≤0.25% | 0.18% |
3. Packaging and storage:
Packaging specification: Packing specification: 25kg/drum, also can be determined according to user's need.
During transportation, it is necessary to protect against sunlight, rain, and high temperatures.
The product should be stored in a cool, dark, ventilated place, away from sources of fire.
4.Safety protection:
Pay attention to labor protection when handling it and avoid contact with skin, eyes, etc.After contact, rinse immediately with plenty of water
Related keywords：
Pivaloyl chloride
CAS No. 3282-30-2
Pivaloyl chloride
CAS No. 3282-30-2
Alias: 2,2-dimethyl-propanoylchlorid;Acetyl chloride, trimethyl-;Neopantanoyl chloride;Pivalolyl chloride;pivaloyl;PIVALOYL CHLORIDE(PVCL);Pivaloyl chloride(Trimethylacetyl chloride);
Molecular formula：C5H9ClO
Molecular weight：120.58
Structural formula：
1.Performance and use:
It is colourless liquid, m.p.-56℃, b.p.105～106℃, n20D1.4120, relative density 0.9790, decompose in water, soluble in ether, benzene, toluene and other solvents.
Uses Trimethylacetyl chloride, also known as pivaloyl chloride, is the intermediate for the production of carbamate insecticide azoxystrobin, and also the intermediate for the herbicide isoemazolone, can be used as a raw material for the synthesis of amide and phenolic ester drugs, used in the production of (hydroxy)benzylpenicillin, cephalosporin (hydroxy)benzyl, ceftolozolin, bis(pivaloyl) adrenaline, etc, and is also used in the synthesis of tert-butyl tert-butyl peroxovaleric acid and other drugs.
Pivaloyl chloride can be used as the intermediate of semi-synthetic penicillin and cephalosporin, as well as the intermediate of pesticide, the intermediate of organic yellow agent of photographic material. In addition, it can be used as an acylating agent for ammonia, Schiff base, pyrrolidone and alcohols.
It is an important acylation reagent. The main role is as a pharmaceutical intermediate, such as for the production of hydroxybenzylpenicillin cefadroxil, cefazolin and bis-pivaloyl adrenaline and other drugs. UsesWidely used as an N-acylating agent for amines, Schiff bases and pyrrolidones, and as an O-acylating agent for alcohols, lactones and sugars.
2.Technical indicators:
ITEM | STANDARD SPEC. | TEST RESULT |
Appearance |
Colorless transparent liquid |
Colorless transparent liquid |
Pivaloyl Chloride | ≥99% | 99.13% |
Pivalic acid | ≤0.25% | 0.20% |
Pivalic anhydride | ≤0.25% | 0.18% |
3. Packaging and storage:
Packaging specification: Packing specification: 25kg/drum, also can be determined according to user's need.
During transportation, it is necessary to protect against sunlight, rain, and high temperatures.
The product should be stored in a cool, dark, ventilated place, away from sources of fire.
4.Safety protection:
Pay attention to labor protection when handling it and avoid contact with skin, eyes, etc.After contact, rinse immediately with plenty of water
Related keywords：
Pivaloyl chloride
CAS No. 3282-30-2
